EFMC-ACSMEDI MedChem Frontiers 2019

Joint Symposium on Medicinal Chemistry Frontiers

 Krakow, Poland    June 10-13, 2019

Programme


10:00

Optional Excursions

15:00

Registration

Opening Session

17:30

Opening of the Symposium & Welcome Address

17:45

PL01 - Derivatives of 1,3,5-triazine as a New Trend in the Search for the 5-HT6 Receptor Ligands with Therapeutic Perspectives

Dr Jadwiga HANDZLIK
MEDICAL COLLEGE OF JAGIELLONIAN UNIVERSITY, Krakow, Poland

18:30

Welcome Reception

08:00

Registration

Matrix Metallo-Proteinases

09:01

IL01 - Unnatural Amino Acids as a Tool for Better Understanding of Endoproteases Substrate Specificity

Prof. Marcin DRAG
WROCLAV UNIVERSITY OF TECHNOLOGY, Wroclaw, Poland

09:30

IL02 - MMP-9 at the Synapse in the Brain and Mind

Prof. Leszek KACZMAREK
NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY, Warsaw, Poland

10:00

IL03 - Target Identification by TAILS N-Terminal Positional Proteomics Leads to Development of a Pharmacological Molecular Corrector for Mutant MALT1 Impaired NF-kB Activation in Immunodeficiency

Prof. Christopher OVERALL
UNIVERSITY OF BRITISH COLUMBIA, Vancouver, Canada

10:30

Coffee Break and Exhibition

Genomics in Drug Discovery : Roles for Chemistry

11:00

IL04 - Remedying the Diseased Genome with Precision-tailored synthetic Gene Regulators (SynGRs)

Prof. Aseem ANSARI
UNIVERSITY OF WISCONSIN-MADISON, Madison, United States

11:30

IL05 - Exploring Bacterial Genomes for Natural Product Discovery and Development

Prof. Alessandra S. EUSTAQUIO
UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, United States

12:00

OC01 - to be selected from the submitted abstracts

12:15

OC02 - to be selected from the submitted abstracts

12:30

Lunch and Exhibition

Advances in Protein Degradation Technologies

14:00

IL06- Targeted Protein Degradation with Small Molecules: How PROTACs work

Prof. Alessio CIULLI
UNIVERSITY OF DUNDEE, Dundee, United Kingdom

14:30

IL07 - The Ubiquitin Proteasome System

Prof. Huib OVAA
LEIDEN UNIVERSITY MEDICAL CENTER, Leiden, The Netherlands

15:00

OC03 - to be selected from the submitted abstracts

15:15

OC04- to be selected from the submitted abstracts

15:30

Coffee Break and Exhibition

16:00

PL02 - Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders

Prof. Krzysztof PALCZEWSKI
CASE WESTERN RESERVE UNIVERSITY, Cleveland, United States

16:45

Poster Session 1
(posters with odd numbers)

GPCRs : a Discovery Powerhouse

09:00

IL08 - G Protein-Coupled Receptors: the Structural Basis for their Pharmacology

Dr Chris TATE
MRC LABORATORY OF MOLECULAR BIOLOGY, Cambridge, United Kingdom

09:30

IL09 - Design of Orexin-1 Receptor Selective Antagonists

Dr Uta LESSEL
BOEHRINGER INGELHEIM, Biberach an der Riss, Germany

10:00

IL10 - Next Generation GPR119 Agonists as Potential Treatment for Cardiometabolic Diseases

Dr Lothar SCHWINK
SANOFI, Frankfurt Am Main, Germany

10:30

Coffee Break and Exhibition

Multi-Targeted Drugs

11:00

IL11 - Charting New Paths in Multi-Target Drug Discovery for Alzheimer’s Disease

Prof. Maria Laura BOLOGNESI
UNIVERSITY OF BOLOGNA, Bologna, Italy

11:30

IL12 - Multiple Targeting - The Histamine H3 Receptor Pharmacophore as Central Element

Prof. Holger STARK
HEINRICH HEINE UNIVERSITY DÜSSELDORF, Duesseldorf, Germany

12:00

OC05 - to be selected from the submitted abstracts

12:15

OC06 - to be selected from the submitted abstracts

12:30

Lunch and Exhibition

Opioid, Pain, Endo-Cannabinoid

14:00

IL13 - Cannabinoid Receptor Type 2 Modulation to Improve Outcomes for Cartilage Repair in the Osteoarthritic Joint

Prof. Katarzyna STAROWICZ-BUBAK
INSTITUTE OF PHARMACOLOGY, POLISH ACADEMY OF SCIENCES, Krakow, Poland

14:30

IL14 - The Huge Potential of Natural Cannabinoids and Synthetic Cannabinoids in Neuroprotection

Prof. Rafael FRANCO
UNIVERSITY OF BARCELONA, Barcelona, Spain

15:00

OC07 - to be selected from the submitted abstracts

15:15

OC08 - to be selected from the submitted abstracts

15:30

Coffee Break and Exhibition

16:00

PL03 - Next Generation Pain Therapeutics for the Opioid Crisis: Design of Bifunctional Nociceptin/Mu Opioid GPCR Ligands as non-Addicting Analgesics

Dr Nurulain ZAVERI
ASTRAEA THERAPEUTICS, Mountain View, United States

16:45

Poster Session 2
(posters with even numbers)

20:00

Banquet

Chemical Biology Tools & Target Engagement Technologies

09:00

IL15 - Protein-Ligand Interactions: How Medicinal Chemistry Contributes to the Understanding of Molecular Recognition

Dr Marc NAZARE
FMP, Berlin, Germany

09:30

IL16 - Adventures in Targeting Protein Lipdation: Breaking Drug Resistance Using Fragment Deconstruction and Chemical Biology

Prof. Edward TATE
IMPERIAL COLLEGE LONDON, London, United Kingdom

10:00

IL17 - Chemical Physiology of Antibody Conjugates and Natural Products
"2018 MedChemComm Emerging Investigator Lectureship"

Dr Goncalo BERNARDES
INSTITUTO DE MEDICINA MOLECULAR, PORTUGAL & UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom

10:30

Coffee Break and Exhibition

Targeted Covalent Inhibitors

11:00

IL18 - Safety First: Covalent Inhibitors from a Safety Perspective

Dr Mickael MOGEMARK
ASTRAZENECA, Mölndal, Sweden

11:30

IL19 - Adventures in Functional Assignment and Inhibition of Metallo-Enzymes

Prof. Christopher J. SCHOFIELD
UNIVERSITY OF OXFORD, Oxford, United Kingdom

12:00

IL20 - Mining the Protein Kinase Cysteinome

Dr Tjeerd BARF
ACERTA PHARMA BV, Oss, The Netherlands

12:30

Lunch and Exhibition

Adding AI to the Drug Discovery Tool Box

14:00

IL21 - AI-based Chemical Synthesis for Accelerating Drug Discovery

Prof. Mark WALLER
UNIVERSITY OF WOLLONGONG, Wollongong, Australia

14:30

IL22 - Applications of Artificial Intelligence in Drug Discovery – Separating Hype From Utility

Dr Pat WALTERS
RELAY THERAPEUTICS, Cambridge, United States

15:00

OC09 - Augmented Intelligence for Compound Design

Dr Michal WARCHOL
ARDIGEN, Krakow, Poland

15:15

OC10 - to be selected from the submitted abstracts

15:30

Closing Remarks